I got my 1st Bachelor's & 1st Master's degree from an online college - Touro University International (TUI). The degrees were in Health Care Management.
I ended up with a 3.7 GPA
I just finished my 2d Master's degree in July - it was in Environmental Health & I got by attending all classes on the campus of East Carolina University (ECU in Greenville, NC). I ended up with a 3.62 GPA.
The main difference with online colleges is that you have more papers to write, but they're usually shorter than the papers at a campus-based college. At TUI, I had to do 1-2 papers per week, but each was only 2-4 pages long. At ECU, I had 1 paper every 10 days, but each was an average of 10-12 pages long. Each class, whether online or at campus required an end of semester exam be taken. For the online courses, the teacher would post a question at a certain day/time & we had 24 hours to answer it - the answer had to be in essay format.
Also, instead of meeting in a classroom, each class will have 1 or 2 days per week where all students in the class must be in a "chat room" on a certain day/time for 30-60 minutes. During the chat, the teacher will usually ask a question, then the students take turns answering the question & debating each other on their responses.
I did not think the actual level of difficulty was any different between the 2 colleges. The papers at ECU were not harder to write, just longer.
My wife did her Health Care Administration degree online from Southern illinois University (SIU) & it was very comparable to my online degree.
While every college is different, I hope this helped!